| abstract |
A 5-amidino-N-(2-aminophenethyl)-2-hydroxybenzenesulfonamide derivative represented by the general formula [I] (wherein R1 is hydrogen or lower alkyl; R2 is hydrogen, optionally substituted lower alkyl, etc.; R3 is di(lower alkyl)amino, lower alkyl, cycloalkyl, etc.; Q is hydrogen or optionally substituted lower alkyl; and Z is hydrogen, hydroxy, etc.) or a pharmacologically acceptable salt of the derivative, which have strong and selective inhibitory activity against activated blood coagulation factor X and are useful as a preventive or remedy for diseases in which the activated blood coagulation factor X participates; a medicinal composition containing the compound; a medicinal use of the compound; and an intermediate for the compound. |