| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3cb959dea36caf5cc3045519c0328b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3c9fc3cb0028234aedb8df651f9d2e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fe91d62ad7f64bb1f703931c5fe46fc1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35cff44499631dd94d903093ccdfa484 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
2002-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1250dd4f76afe8552662c5b5ccacb643
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de675c7da6582fa73b714c98ce8072db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9fea2a2368133795fa4f879444b0f97 |
| publicationDate |
2003-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-03014142-A2 |
| titleOfInvention |
Phosphorylated histone h2b as an apoptosis marker |
| abstract |
The present invention is directed to the generation of antibodies against an α-phosphorylated serine 14 residue on Histone 2B. This postranslational modification of the amino terminus of Histone 2B is associated with cells that are about to enter or are already undergoing apoptosis. These antibodies are useful in identifying apoptotic cells and serve as diagnostic and screening tools. The present invention is also directed to the Mst1 kinase and the isolation of compounds that modulate the activity of Mst1. This kinase has been identified as the enzyme responsible for creating this postranslational modification on Histone 2B in vivo. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9594084-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1483415-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1483415-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GR-1009240-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018069740-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018069741-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10408831-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1896849-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013103899-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10564167-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005019826-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016038145-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GR-1009241-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1896849-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9128086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013192298-A1 |
| priorityDate |
2001-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |