| abstract |
Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula: (I), wherein Ar?1 and Ar2¿ independently represent aryl or heteroaryl and Y represents a bond or a (C(R3)2)1-3 group. Also disclosed is a method of inhibiting gamma secretase, and a method of treating Alzheimer s disease using the compounds of formula I. |