| abstract |
The invention relates to a method for the continuous production, using neither solvents nor mastication, of self-adhesive compounds on the basis of SBC that includes at least one pharmaceutically active substance in a continuously working unit that comprises a filling and a compounding section. The method comprises the following steps: a) advancing a pre-batch from SBC, optionally together with a parting agent and at least one pharmaceutically active substance into the filling section of the unit, optionally advancing low-molecular SBC, fillers, plasticizers, tackifiers, resins and/or additives, b) transferring the advance components of the self-adhesive compound from the filling section to the compounding section, c) optionally adding those components of the self-adhesive compound that were not filled into the compounding section such as low-molecular SBC, fillers, plasticizers, tackifiers, resins and/or additives, d) optionally adding further pharmaceutically active substances to the compounding section of the unit, e) producing a homogeneous self-adhesive compound in the compounding section, and f) extruding said self-adhesive compound. |