| abstract |
There is provided a medical device adapted for insertion into a human or animal body, characterised in that its exterior surface is coated with 1) an inner first layer of a biocompatible carrier comprising a sulphated glycosaminoglycan and providing sustained release of a biologically active agent dissolved or dispersed therein; 2) an outer second layer consisting of a film of said biologically active agent applied on said inner first layer, where said film optionally may contain at least one non-polymeric adjuvant, diluent or carrier. The present medical device is especially well suited for treatment or prevention of restenosis and disorders related thereto, and the sulphated glycosaminoglycan provides improved biocompatibility. |