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filingDate 2002-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba5608a47213f36a3072ca1a1d0d9704
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publicationDate 2004-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-03009812-A3
titleOfInvention Use of glycosylceramides as adjuvants for vaccines against infections and cancer
abstract The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes glycosylceramide, preferably α-galactosylceramide (α-GalCer). According to the present invention, the use of glycosylceramide as an adjuvant is attributed at least in part to the enhancement and/or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.
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priorityDate 2001-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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