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filingDate 2002-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_def4cd9f44b63e0810c605f511eaadab
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publicationDate 2003-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-03004700-A1
titleOfInvention Method and system for detecting inter-chromosomal imbalance by fluorescent in situ hybridization (fish) on interphase nuclei
abstract The invention concerns a system for detecting chromosomal imbalance by in situ hybridization of fluorescent probes on interphase nuclei, comprising the following phases: hybridizing in situ fluorescent probes on two separate chromosomes; exposing each probe with a different fluorochrome; measuring the intensity signals corresponding respectively to each probe thus exposed, on an assembly of nuclei, said measurement being carried out within a control cell population and within a cell population subjected to detection; calculating a ratio between the signals corresponding to each of the probes, said ratio calculation being carried out on said control cell population to provide a reference ratio and said population subjected to detection; comparing the fluorescence ratio corresponding to the population subjected to detection with the reference ratio; and processing the result of said comparison to detect an inter-chromosomal imbalance.
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