| abstract |
The invention relates to synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to synthesis methods of the intermediate of formula (VI) wherein Ra' and Rc' are each independently of the other hydrogen or hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula (XVI) wherein Ra' and Rc' are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further intermediates and methods for their preparation. |