http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03004141-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84294094be0a7da10d0e987896ba22f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4209354dce74930bf7d6913c8065e76b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba5b3347b481dc15631b286deba3a508 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc5c2bf54d4cd02860198d44ffefa24b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2002-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe2c3799641873d9514069d518012c9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d345aa5dd8925ccd32ba3a1c79a6f5f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12c7803a90524e181dee7bd5cf25008c |
| publicationDate | 2003-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03004141-A2 |
| titleOfInvention | Kinase mimic catalysts for asymmetric synthesis of phosphorylated insitols and cycloalkanols |
| abstract | The present invention provides peptide-based phosphorylation catalysts (PBPC's) for the asymmetric monophosphorylation of cyclitols, particularly myo-inositols. The PBPC's of the invention effect a regio and enantioselective phosphorylation of a myo-inositol in a manner analogous to enzymatic kinases, thereby functioning as effective 'kinase mimics.' Although orders of magnitude less complex in terms of structure than macromolecular proteins, the PBPC's of the invention control product formation with high enantioselectivity (>98% ee). The synthetic (+)-myo-inositol-1-phosphate is optically and spectroscopically equivalent to naturally occurring compound. The ability of the low molecular weight PBPC's of the present invention to mimic stereoselective enzymes represents a powerful approach toward catalytic asymmetric synthesis of biologically important molecules, and for mechanistic modeling of biochemical transformations to enable their use in drug applications. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10131928-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015001312-A1 |
| priorityDate | 2001-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 155.