http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03004017-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8366782f91765010cb631c996da4d535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3082bdc3c9967d59703f4fd64438cdd8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2002-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12a654fb76bab8a4608178b8d27302bc |
| publicationDate | 2003-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03004017-A1 |
| titleOfInvention | Synergistic compositions of n-acylhomoserine lactones and 4-quinolones |
| abstract | A composition having immunosuppressant activity comprises at least one compound of the formula (I) in which R is an acyl group of the formula (II) wherein one of R?1 and R2¿ is H and the other is selected from OR4, SR4 and NHR4, wherein R4 is H or 1-6C alkyl, or R?1 and R2¿ together with the carbon atom to which they are joined form a keto group, and R3 is a straight or branched chain, saturated or unsaturated aliphatic hydrocarbyl group containing from 8 to 11 carbon atoms and is optionally substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR5R6 wherein each of R?5 and R6¿ is selected from H and 1-6C alkyl or R?5 and R6¿ together with the N atom form a morpholino or piperazino group, or any enantiomer thereof; and at least one compound of the formula (III): wherein R7 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing from 1 to 18 carbon atoms which may optionally be substituted by one or more substituent groups selected from halo, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl and NR12R13, wherein each of R?12 and R13¿ is independently selected from H and 1-6C alkyl or R?12 and R13¿ together with the N atom to which they are attached form a saturated heterocyclic group selected from piperidino, piperazino and morpholino; R8 is a group selected from H, -OH, halo, -CHO, -CO¿2?H and CONHR?14¿ wherein R14 is H or a 1-6C alkyl; each of R?9, R10 and R11¿ is independently selected from H, -CH¿3?, -OCH3 and halo; or a non-toxic pharmaceutically-acceptable salt thereof. The determined immunosuppressant activity of the composition is greater than the sum of the activities of the individual components of the composition when determined separately. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114805049-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7371779-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10588900-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7335779-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7338969-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501969-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2078713-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11058676-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012532095-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011001419-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9242951-B2 |
| priorityDate | 2001-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 401.