Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14c8aaca1a5623194ef50a5be15be6aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b99e837de1b602ccd92ab4b68e71274 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3eb6ffbe2a3a0cc45baad2b5370c8f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5181f7bc41146d952cf4e72f866a39ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ee0c098ff09f3781c3645984d647c38 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-715 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate |
2002-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_241dc6b7fe1d664f2830c6e973cc1bd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1802c71daf03c9f9ef669e6ac84b12f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e33a3e61db9f00b8bcf250c4ee7b815d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ed23c4d05fcee301273a890b085f354 |
publicationDate |
2003-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-03002726-A2 |
titleOfInvention |
Cellular reporter gene assay with a ligand amplifying feedback loop |
abstract |
The present invention relates to a loop dependent cellular detection system for ligands, preferably cytokine ligands based on coexpression of a ligand and a cognate receptor. The presence of the ligand induces its own expression in the cell via a signalling cascade, which starts at the cognate receptor for said ligand. This autostimulatory signalling loop acts as an amplifier so that minute quantities of the ligand can be detected and/or measured in a quantitative way. The system allows detecting and/or measuring of amounts of ligand that cannot be detected and/or measured in another way. |
priorityDate |
2001-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |