http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03000858-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate | 2002-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb5c409820992928ec5e0a4b7de760ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87146fbe3c1cc4bd970ce16f1569fcb1 |
| publicationDate | 2003-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-03000858-A2 |
| titleOfInvention | Pharmacological targeting of bacterial dna ligase for treatment and prevention of bacterial infections |
| abstract | This invention provides methods for the discovery of molecules that target an essential step of bacterial DNA replication - the sealing of DNA strands by NAD+-dependent DNA ligase. Specific structural components of NAD+-dependent DNA ligase that are important for the reaction of DNA ligase with NAD+ and that comprise a putative binding site for the NMN component of NAD+ were identified. The invention also includes recombinant DNA ligase enzymes that are defective in their reaction with NAD+, but active in the ligation of pre-adenylated DNA nicks. An underlying principle of this invention is the use of NAD+-reactive and NAD+-defective ligases to identify molecules that specifically bind to the NAD+-binding site of DNA ligase and thereby interfere with the reaction of DNA ligase with NAD+. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2006016146-A1 |
| priorityDate | 2001-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 176.