| abstract |
The invention relates to cytokine receptor binding peptide constructs and methods of producing same. Preferably the constructs are interferon receptor binding peptide constructs comprising at least one interferon, receptor binding domain inserted into an appropriate scaffold that maintains the binding domain in a configuration suitable for binding to the interferon, receptor. Preferably, the interferon binding peptide constructs comprise three interferon binding domains, one from each of the interferon binding domains of human interferon type 1 (amino acid regions 10-35, 78-107 and 123- 166, preferably 29-35, 78-95 and 130-140, respectively), the scaffold maintaining the three domains in a configuration suitable for binding to their binding sites on the interferon type I receptor. The resulting construct preferably has a biological activity comparable to naturally occurring interferon. |