| abstract |
The present invention relates to fatty acid analogues of the general formula I: R1- [xi - CH2]n - COOR2 ; wherein R1 is ; a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or; a C1-C24 alkyne, and/or; a C1-C¿24 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and; whereinR2 represents hydrogen or C1-C4 alkyl, and; wherein n is an integer from 1 to 12, and; wherein i is an old number and indicates the position relative to COOR2, and; wherein Xi independent of each other are selected from the group comprising, O, S, SO, SO2, Se and CH2, and; with the proviso that at least one of the Xi is not CH2; which can be used for the treatment and/or prevention of inflammatory disorders. Further, the invention relates to methods for enhancing the endogenous production of interleukin-10 (IL-10) and suppressing the production of interleukin-2 in mammalian cells or tissues. The invention also relates to a method for inhibiting the proliferation of stimulated peripheral mononuclear cells. |