| abstract |
A compound other than Ser- His, having the structure (Ser/Cys) - Xaam - His - Xaan (EM'), where 0<=(m+n)<=12, is useful as a nuclease or protease. A compound having the structure EM-L-BM, where EM is EM' above or Ser-His, L is a linker and BM is a nucleotide or amino acid sequence binding moiety, is also useful as a nuclease or protease. The compounds, EM and EM-L-BM which act as nucleases are useful in labeling a nucleic acid by nick translation. |