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filingDate 2001-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2002-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0239983-A3
titleOfInvention Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
abstract Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly fenofibrate, are provided. The compositions comprise a therapeutically effective amount of an active agent and a solubilizer. The solubilizer is selected to effectively solubilize agent in the composition. The solubilizers employed as part of the invention include: a vitamin E substance; monohydric alcohol esters such as trialkyl citrates, lactones and lower alcohol fatty acid esters; nitrogen-containing solvents; phospholipids; glycerol acetates such as acetin, diacetin and triacetin; glycerol fatty acid esters such as mono-, di- and triglycerides and acetylated mono- and diglycerides; prophylene glycol esters; ehtylene glycol esters; and combinations thereof. The pharmaceutical dosage forms contain the compositions in a suitable dosage form unit such as a capsule. Methods of treating patients comprising administering the compositions are also provided.
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