| abstract |
Compounds of the general formula (I) which are metabolically stable and exhibit PGD2 receptor antagonism, wherein Y is a bicyclic ring; R1 is optionally substituted heteroaryl; R2 is hydrogen or the like; R3 is -CH¿2?-CH2-CH2-CH2-CH=CH-COOR?4,- CH¿2-CH2-CH2-CH2-X1-CH2-COOR4, -CH2-CH=CH-CH2-X1-CH2-COOR4, or -CH¿2?-CH2-CH2-CH2-COOR?4; R4¿ is hydrogen or the like; and X1 is -O- or the like. |