abstract |
A new fermentative process for the preparation of D-p-hydroxyphenylglycine (D-HPG) or D-henylglycine (D-PG) in enantiomerically pure form is disclosed. Precursors for the formation of D-HPG and D-PG are withdrawn form the common aromatic amino acid pathway, converted to p-hydroxyphenylglyoxylate or phenylglyoxylate, and are finally converted to D-HPG or D-PG by the action of a stero-inverting D-aminotransferase. |