http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0234910-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad18f23c9bab01a7c1cf73acd7a4e3ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dfcbce6280371b20d0e72a8950b1f68b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db8acd71f5994544bda6df3f27a3f51e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-72 |
| filingDate | 2001-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d0a28980fc675a56d9324f917040657 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_743eb89627452df3e234ff3233acc975 |
| publicationDate | 2002-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-0234910-A2 |
| titleOfInvention | Method for modulating granzyme b uptake and for identifying modulators thereof |
| abstract | The present invention relates to the identification of CI-MPR as the receptor responsible for binding and internalization of grB into cells. In addition, the present invention relates to the binding and/or internalization of grB by CI-MPR as an event necessary to enable grB-mediated apoptosis in cells. The present invention further identifies the binding and/or internalization of grB through CI-MPR as a target which is used by cancer cells to evade the grB-mediated apoptosis and clearing by the immune system. The present invention further provides assays to identify modulators of grB binding to CI-MPR and/or internalization of grB thereby. In addition, the invention provides methods to correct a disease or condition associated with a defect in grB binding to CI-MPR and/or internalization of grB thereby, which comprises an administration of an effective amount of a modulator of grB-CI-MPR interaction. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7074911-B2 |
| priorityDate | 2000-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 604.