abstract |
The present invention relates to novel immortalized pre-osteoblast cells lines derived from the periost and capable of differentiating to osteoblasts. In particular, the present invention pertains to teh use of such cell lines in asays for detecting substances controlling the differentiation of pre-osteoblasts to osteoblasts and for detecting substances enabling improved bone formation, maintenance of bone mass, bone repair and for preventing the onset of osteoporosis. |