| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5181f7bc41146d952cf4e72f866a39ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e81c667688d02980f0b20dfc116c88a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9df5cb810f1ff73f1f7f29bca9535674
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fbbff63c093727f72229694e80fab782 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52 |
| filingDate |
2001-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bf16d63aa7fe6846864b55eddd13b11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_620166c76602cb2742696b317ef68d8d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7180c8025054c6ab9493da2381087c4 |
| publicationDate |
2002-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0234780-A2 |
| titleOfInvention |
Hetero-oligomeric compounds derived from the tnf cytokine superfamily and their use |
| abstract |
The invention relates to a method to form artificial, hetero-oligomeric complexes of proteins that do normally occur in homo-oligomeric complexes. Said hetero-oligomeric complexes do have a biological activity that is similar or identical to the activity of the homo-oligomeric complexes.The current invention also relates to a method to use said hetero-oligomeric complexes to screen for compounds that can stabilize said hetero-oligomeric complexes, or to screen for compounds that dissociate said hetero-oligomeric complexes into monomers, which are not biologically active, or show a biological activity, which is clearly distinct from that of the hetero-oligomeric complexes, or to screen for compounds that inhibit the oligomerisation or reoligomerisation of monomers in oligomeric complexes.Furthermore, the invention relates to pharmaceutical compositions comprising said compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8734795-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9272025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807784-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7811983-B2 |
| priorityDate |
2000-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |