| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_92d71a3e23389a3bca747290fc6464cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68a59151186b87313206b1961058ecb1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0083 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-577 |
| filingDate |
2001-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d3e44daa40dbbd4e61b1f2a0d2499f |
| publicationDate |
2002-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0230987-A1 |
| titleOfInvention |
Antihuman heme oxygenase-1 monoclonal antibody |
| abstract |
A monoclonal antibody showing no cross reactivity with a stress non-induced enzyme human HO (heme oxygenase)-2 but enabling specific detection of stress-induced human HO-1 and thus being capable of inhibiting the human HO-1 activity; a method of assaying or detecting human HO-1 by using this antibody; a method of detecting stress in cells or tissues; etc. By measuring the total HO activity in the presence and absence of the antihuman HO-1 monoclonal antibody, the human HO-1 in cells or tissues is quantified. By using two monoclonal antibody types as described above, human HO-1 in cells or tissues is quantified by ELISA to thereby detecting stress. Cells or tissues are treated successively with para-formaldehyde and then with saponin and the above-described monoclonal antibody followed by fluorescent staining. Thus human HO-1 is detected and, in its turn, a stress-response is detected. |
| priorityDate |
2000-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |