| abstract |
The invention provides a mammalian cDNA which encodes a mammalian ATP-binding cassette protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of breast disorders, particularly breast proliferative fibrocystic disease, breast adenocarcinoma, and drug resistance. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system. |