| abstract |
Provided are novel compounds exhibiting excellent inhibitory activities against AMPA receptor and/or kainate receptor, i.e., compounds of the general formula (I), salts thereof, or hydrates of both wherein A?1, A2 and A3¿ are each independently C¿3-8? cycloalkyl, C3-8 cycloalkenyl, a 5- to 14-membered nonoaromatic heterocyclic group, a C6-14 aromatic carbocyclic group, or a 5- to 14-membered aromatic heterocyclic group, any of which may be substituted; Q is O, S, or NH; Z is C or N; X?1, X2 and X3¿ are each independently a single bond, optionally substituted C¿1-6? alkylene, optionally substituted C2-6 alkenylene, optionally substituted C2-6 alkynylene, -NH-, -O-, -NHCO-, -CONH-, -SO0-2-, or the like; R?1 and R2¿ are each independently hydrogen or optionally substituted C¿1-6? alkyl, or alternatively R?1 and R2¿ may be united in such a way that CR2-ZR1 forms C=C; and R3 is hydrogen, optionally substituted C¿1-6? alkyl, or the like, or alternatively R?3¿ may unite with any atom on the ring A1 or A3 to form together with the atom an optionally substituted C¿5-8? carbocycle or an optionally substituted 5- to 8-membered heterocycle. |