| abstract |
The present invention relates to novel cofactors of the Pregnane X Receptor which we call CF1, CF2, CF3, CF4 and CF 44 the isolated nucleic acid sequences thereof and the isolated proteins thereof. The invention further relates to processes for isolating and/or producing the nucleic acids or the proteins as well as methods of use of these cofactors, such as inhibiting or activating the binding of the cofactors to PXR. |