http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0216642-A1

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http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b6bb4a89ea197b0b553f98b4a609345
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1027
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filingDate 2001-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1ba1f3e1cd61b0aaa5a0dcac715231e
publicationDate 2002-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-0216642-A1
titleOfInvention Methods and compositions for directed molecular evolution using dna-end modification
abstract Methods as depicted in figure 3, for directed evolution are described where genetic elements are randomly cleaved to permit the deletion or addition of polynucleotides or both to create a library of related genetic elements with additions or deletions. Corresponding library populations are also described. These processes allow a significant sampling of sequence space which is necessary for directed evolution of genes. Further described are methods for effecting very small nucleotide deletions in genetic elements of interest.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013540439-A
priorityDate 2000-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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