Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e29526f284c0155fd79806c9dd5a1c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2c632b9a832250171d96ee3b3b9e2117 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a73f980d6841d9c438f1b7767ecea26a |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0318 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
filingDate |
2001-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a118ab1a83422161264b8193b4481619 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_536692bc5759e3bbcbed1686cb46466e |
publicationDate |
2002-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
WO-0216417-A2 |
titleOfInvention |
Transgenic animal model for neurodegerative disease and uses thereof |
abstract |
The invention provides a transgenic non-human mammal comprising nucleated cells containing a transgene encoding an ataxin-2 polypeptide comprising a polyglutamine tract. In particular, the transgenic-non-human mammal can be a mouse. The invention also provides methods of using a transgenic non-human mammal expressing SCA2 encoding an ataxin-2 polypeptide to identify a therapeutic agent for use in treating a neurodegenerative disease by administering a compound to a transgenic non-human mammal expressing SCA2 encoding an ataxin-2 polypeptide and screening the transgenic non-human mammal for an improved neurological response associated with a neurodegenerative phenotype of the transgenic non-human mammal, thereby identifying a therapeutic agent for use in treating the neurodegenerative disease. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1525466-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007124751-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1356278-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1525466-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1704778-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2377940-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3668891-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11066669-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8173861-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1356278-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007124751-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286485-B2 |
priorityDate |
2000-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |