| abstract |
Tetrazotyl-phenyl acetamides of formula (1) wherein Z is (2) one of R1 or R2 is (3) and the other is hydrogen, halogen, lower alkyl sulfonyl, perfluoro lower alkyl, cyano, or nitro; R3 is cycloalkyl; R4 is -C(O)-NHR6 or a five- or six-membered heteroaromatic ring connected by a ring carbon atom to the amide group, are active as glucokinase activators, and are able to increase insulin secretion, which makes them useful for treating type II diabetes. |