| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0d6c5363f31f2c5b66751b2ed6c646e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2262dd1649f7cd88ee89c4d6fc68c39d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1274cb74ee7ad52031421e158ec4477e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b045d97b789f6e65d4196273612490c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6421 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2001-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b58db8a19400bfa6e0a9965bb80981f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcb2c45b774e09953b7099b59950e3d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1657b4881ff23bc4a293f65cba1a8d8 |
| publicationDate |
2002-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0210354-A2 |
| titleOfInvention |
Secretase/sheddase with asp-ase activity on the beta-site app-cleaving enzyme (bace, asp2, memepsin 2) |
| abstract |
A novel Asp-ase activity, referred to as BACE secretase/sheddase, has been found to cleave the ectoddomain of BACE after Asp379 (SQDD↓) and Asp407 (VVFD↓), and likely after Asp451 (PQTD↓). The cleavage of BACE by BACE secretase/sheddase renders BACE soluble which in turns appears to enhance the generation of the amyloidogenic peptide Aβ, which has been implicated as a major factor in the etiology of Alzheimer's Disease. The current invention concerns the modulation of this novel BACE secretase/sheddase activity for such applications as the prevention or treatment of a neurodegenerative disorder that is characterized by the generation of Aβ protein, including Alzheimer's Disease. The invention further comprises a method for the identification of an agent that can alter the ability of BACE secretase/sheddase to associate with and process a known substrate, a method of determining whether an individual is at risk of developing a neurodegenerative disorder that is characterized by the generation of Aβ protein (such as Alzheimer's Disease) and a kit comprising a vessel or vessels containing BACE secretase/sheddase as well as at least one known substrate of this enzyme, namely, BACE or BACE fragments, or the indirect substrate βAPP. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/HR-P20040712-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03070760-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8329886-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8216577-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906370-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008129023-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102887953-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2008129023-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02101232-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2368907-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7794719-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03070760-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02101232-A3 |
| priorityDate |
2000-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |