| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01f4dfbf7e928b2477534a09534993e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dd0759950a6de264b065af44e0f1840
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00fa91b7878acde68922452f6f55eb31 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70539 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 |
| filingDate |
2002-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_738a0b1bb2d80b640268a4691cf711dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48ba0c7570c36ca26da155aa965e5042 |
| publicationDate |
2002-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02102840-A2 |
| titleOfInvention |
Multiners of class i major histocompatibility complexes cantaining modified beta2-microglobulin proteins |
| abstract |
The present invention provides a multimers of class I Major Histocompatibility Complexes (MHCs) having a modified β2-microglobulin whose binding to CD8 is inhibited. Such MHCs are capable of inhibiting CD8+ T cell response, particularly by inducing apoptosis or anergy of the T cell. The invention also provides nucleic acids encoding such molecules, and the use of such multimers and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2374470-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101442209-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102869368-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11484571-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8449889-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2582389-C2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8022190-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007136778-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011125029-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7977457-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9616112-B2 |
| priorityDate |
2001-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |