| abstract |
This invention relates to methods of delivering a medium to highly lipophilic drug to the systemic circulation through the lymphatic transport system including the oral administration to a subject in the fasted state of a formulation comprising the lipophilic drug and a component capable of stimulating the production of endogenous lipid, or a component selected from medium to long chain lipids, pharmaceutically acceptable surfactants and combinations thereof, wherein the component is present in an amount sufficient to enhance or promote lymphatic transport of the lipophilic drug, and corresponding methods for avoiding lymphatic transport. |