http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02098216-A1
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d0748ba2c51c96c7207df8ecdaa444e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4dc4e3deabf460af807e35872e3d9c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3e0a5b397c678d2869e70182b598a03 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-103 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0008 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43531 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate | 2002-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d2c4eea004f3ee62d02a18c9771589cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9b81908bb68027b0396d2071aa68f82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26aed657076622886b19b98b11da8b3a |
publicationDate | 2002-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | WO-02098216-A1 |
titleOfInvention | Animal model for allergy |
abstract | The invention relates to model systems for allergic conditions, and in particular to in vivo model systems in a large animal. The model systems of the invention are especially useful for providing large numbers of activated or non-activated eosinophils, for the discovery and evaluation of novel anti-inflammatory drug targets and for providing a model for the in vivo study of asthma and the effects of allergy treatments. In a preferred embodiment the animal is a sheep.In one embodiment, repeated infusion of house dust mite allergen (HDM) into the mammary gland is used to induce a specific allergic response, which is characterised by the recruitment of inflammatory cells, particularly eosinophils, into the mammary lumen; these cells can be harvested from peripheral blood and mammary lavage (MAL). In a second embodiment, the mammmal is immunised with soluble antigen, for example by repeated subcutaneous immunisation, and then subjected to a single challenge with the same antigen administered directly to the lung. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4219552-A2 |
priorityDate | 2001-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 337.