| abstract |
Disclosed herein are methods for identifying peptides that are serologically reactive with samples from HIV-infected subjects who control viremia (LTNP or viremia controllers) at a greater frequency and binding affinity than samples from subjects with progressive HIV disease (HIV progressors). Also disclosed are compositions and methods for using the compositions in the diagnosis, treatment, and prevention of HIV infection, AIDS or both. The compositions of the present invention include peptides that are serologically reactive with samples from viremia controllers at a greater frequency and binding affinity than samples from HIV progressors, polynucleotides encoding such polypeptides, binding agents such as antibodies, antigen presenting cells (APCs), immune system cells ((e.g.), T cells), and combinations thereof. |