| abstract |
A method of coupling an alcohol group of an organic compound to a multidentate nucleophilic compound, which method comprises adding to a reaction vessel containing an activating agent, said nucleophilic compound, said alcohol and a trisubstituted phosphine or trisubsituted phosphite, wherein the trisubstituted phosphine or trisubstituted phosphite and the activating agent together form a redox system which is able to operate a Mitsunobu reaction, resulting in formation of a coupled compound. The method is particularly useful for preparing compounds of formula (I) wherein R8 is the residue of a multidentate nucleophilic compound. |