| abstract |
The present invention discloses insulin producing cells derived from human embryonic stem cells. Methods of generating, enriching, selecting, cloning and isolating populations of insulin-producing embryonic cell lines are disclosed. insulin production in these cells can be glucose responsive, or otherwise regulatable. Advantageously, these insulin-producing cells can be stable cell lines, derived from stable transfectants of hESC. Methods of using these cells, cell populations or cell lines particularly for cell therapy are disclosed., |