| abstract |
Arginine derivatives represented by the following general formula or medicinally acceptable salts thereof: [wherein Ar1 and Ar2 are each independently phenyl, substituted phenyl, naphthyl, substituted naphthyl, or an aromatic heterocyclic group containing one or more atoms selected from among nitrogen, oxygen and sulfur; Y1 is C1-5 alkylene, C2-5 alkenylene, or a single bond, with the proviso that the C1-5 alkylene may contain a carbon atom substituted with phenyl, substituted phenyl, naphthyl, substituted naphthyl, or C1-10 acylamino; Q is carbonyl or sulfonyl; and Y2 is C1-5 alkylene which may contain a carbon atom substituted with phenyl, substituted phenyl, naphthyl, substituted naphthyl, hydroxyl, carbamoyl, mono(C1-5 alkyl)amido, or di(C1-5 alkyl)amido]. Peptidic ligands are provided, which have affinity and specificity for MC4 receptor. |