| abstract |
The invention provides compounds useful as PGI2 receptor agonist and pharmaceutical compositions, particularly pharmaceutical compositions containing as the active ingredient compounds represented by the general formula (1) or pharmaceutically acceptable salts thereof: (1) wherein R1 and R2 are each independently optionally substituted aryl; Y is N, CH, or the like; Z is N, CH, or the like; A is NH, NR5, O, S, ethylene, or the like; R5 is alkyl or the like; D is alkylene or alkenylene; E is phenylene or a single bond; G is O, S, CH2, or the like; R3 and R4 are each independently hydrogen or alkyl; and Q is carboxyl, alkoxycarbonyl, tetrazolyl, carbamoyl, N-(alkylsulfonyl)carbamoyl, or the like. |