| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c4a88beb15263fd96da17c26d345de9d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0623
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-077
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0797
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2002-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3116a0c643dcebb0741b24124aa2088a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd00cfb4c467dc2d0001af12a40df529
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ee5e78bfe4050bfc0276216c29cc25f9 |
| publicationDate |
2002-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02086082-A2 |
| titleOfInvention |
Isolation of neural stem cells using gangliosides and other surface markers |
| abstract |
During the growth and study of NSCs, a range of molecules present on the surface of multipotent neural stem and progenitor cells (NSCs) were identified. These markers were identified using a number of human and murine neural stem cell lines, including retinal stem cells (RSCs). The NSC-specific markers identified included gene products as well as non-protein molecules and sugar epitopes not directly coded in the genome. Together with surface markers which were determined to be absent from the surface of hNSCs, the molecules described herein provide a means to enrich for neural stem cells, or neural progenitor subpopulations, particularly using combinatorial cell sorting strategies. These same molecules also represent targets for pharmacological manipulation of NSC populations and subpopulations, both in vivo and ex vivo. Furthermore, these molecules provide potential targets for therapeutic manipulation of other neural precursor-related cell types including malignant conditions as well as other diseases originating from, or preferentially affecting, various uncommitted or replication-competent cell types. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109069545-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1354943-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018011527-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1354943-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018033596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1674566-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11634687-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1674566-A4 |
| priorityDate |
2001-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |