| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5a33981f4c39337b6f0788c4f7b9c3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42dcb8afd289e295b65f450020cbfdb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-115 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2002-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c71514b79c0ea96383bddff5d450fd7 |
| publicationDate |
2002-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02083837-A1 |
| titleOfInvention |
Methods for identifying small molecules that bind specific rna structural motifs |
| abstract |
The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid ('RNA'). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7888005-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2319318-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087069-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087070-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087884-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2363025-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7939468-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8278085-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7927791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829503-B2 |
| priorityDate |
2001-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |