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filingDate 2002-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16ac1555f6c2c44823c17da23498269d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b905a0a97ecaaf10cfd119ca8c12050
publicationDate 2002-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-02083729-A2
titleOfInvention Polypeptides derived from amyloid precursor peptide (app) and their uses
abstract The invention provides a compound having formula X1-Arg-Xaa-Arg-X2 in which X1 and X2 are up to 30 amino acid residues and Xaa is an amino acid residue. A preferred compound is the tripeptide Arg-Glu-Arg which corresponds to amino acid residues 328 to 330 of human amyloid precursor protein. The invention further provides a derivative of a polypeptide having the formula: X1-Arg-Xaa-Arg-X2 wherein X1 and X2, which may be the same or different, each represents from zero to 30 natural or synthetic amino acid residues or derivatives thereof and Xaa represents a natural or synthetic amino acid residue or derivative thereof, at least one functional group of at least one said amino acid residue or derivative thereof being protected by a protective group. The compounds of the invention are believed to be useful in the treatment of Alzheimer's disease and as cognitive enhancers.
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