| abstract |
The invention provides isolated nucleic acids molecules, designated 47508 nucleic acid molecules, which encode novel human histone deacetylase members. The invention also provides antisense nucleic molecules, recombinant expression vectors containing 47508 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47508 gene has been introduced or disrupted. The invention still further provides isolated 47508 proteins, fusion proteins, antigenic peptides and anti-47508 antibodies. Diagnostic methods utilizing compositions of the invention are aslo provided. |