| abstract |
The present invention relates to diazepine derivatives of formula (I) wherein R represents hydrogen or C1-4 alkyl; R1 represents hydrogen or C1-4 alkyl; R2 represents trifluoromethyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy or halogen; R3 represents halogen or C1-4 alkyl; R4 represents hydrogen, halogen, C1-4 alkyl or COR6; R5 represents hydrogen, C1-4 alkyl or R5 together within the R1 represents C3-7 cycloalkyl; R6 represents hydroxy, amino, methylamino, dimethylamino, 5 membered heteroaryl group containing 1 to 3 heteroatoms selected independently from oxygen, sulphur and nitrogen or a 6 membered heteroaryl group containing 1 to 3 nitrogen atoms; m or n are independently zero or an integer from 1 to 3; X and Y are independently NR7 or methylene; provided that when X is NR7, Y is methylene and when X is methylene, Y is NR7; R7 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl;and pharmaceutically acceptable salts and solvates thereof;to process for their preparation and their use in the treatment of condition mediated by tachykinins. |