| abstract |
The present invention provides Dynamic Action Reference Tools, or DARTs, and methods of making and using DARTs. DARTs can be used, for example, for the isolation and analysis of nucleic acids, polypeptides, and the like, for regulating biological activities and investigating inter-molecular interactions, and the like. A DART is a molecule that includes a Molecular Shaft covalently linked to a Linkage Polypeptide that is covalently linked to a Molecular Point. DARTs, and DART libraries, can be formed and manipulated in vivo or in vitro. DARTs can be purified, and portions of DARTs can be exchanged with portions of other DARTs. |