| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27400970a111c9d774191e9607789468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0272f6a0f14eab75d1c325b2282ddb03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb141b396e502bfce986c491d722e401 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2002-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_831c9d99927838f64e8c23c81c89d33c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ad6458ae8563fb31f42f859be3ffa26 |
| publicationDate |
2002-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02074931-A2 |
| titleOfInvention |
Inhibitors and disassemblers of fibrillogenesis |
| abstract |
Methods and compositions are presented that inhibit fibril formation and/or bring about disassembly of pre-formed fibrils. Compositions include peptides with short beta-strands with two faces (Figure 1): one that can bind to beta-amyloids through hydrogen bonds, and one which blocks propagation of hydrogen bonding needed to form fibrils. Thus, short congeners of the fibril protein containing N-methyl amino acids or esters are provided for the inhibition of fibril formation ad for the disassembly of preexisting or pre-formed fibrils. Specific aspects address beta-amyloid fibrils; prion mediated fibrils; Huntington protein fibrils. Methods for screening for potential fibril inhibitors and disassemblers, diagnostic analysis and treatments are provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014141445-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004053484-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004053484-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014103481-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9745349-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113406234-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113406234-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107698674-A |
| priorityDate |
2001-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |