| abstract |
The invention relates to indirubin derivatives, which maintain a radically increased solubility while preserving the biological activity at the same time by establishing a quaternary center in the R1 position. The invention also relates to the production of the indirubin derivatives, to their intermediate products for the production, and to their use as a medicament in the treatment of cancer such as solid tumors and leukemia, of autoimmune diseases such as psoriasis, alopecia and multiple sclerosis, of chemotherapeutic drug-induced alopecia and mucositis, of cardiovascular diseases such as stenoses, arterioscleroses and restenoses, of infectious diseases such as those caused by unicellular parasites such as Trypanosoma, Toxoplasma or Plasmodium or by fungi, of nephrological diseases such as glomerulonephritis, of chronic neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis, Parkinson's disease, AIDS dementia, and Alzheimer's disease, of acute neurodegenerative diseases such as ischaemia of the brain and neurotrauma, of viral infections such as cytomegalic infections, herpes, hepatitis B and C, and of HIV diseases. |