http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-02070716-A1

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filingDate 2002-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_014b8689fef5f55e43719a333da9f2b9
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publicationDate 2002-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-02070716-A1
titleOfInvention Allergen ole e 9 from olea europaea, recombinant dna coding for said allergen, the production and use thereof
abstract The invention relates to the production of the recombinant allergen Ole e 9 from Olea europaea in Pichia pastoris yeast for use in the diagnosis and treatment of allergies and to the system for isolating and purifying said allergen. The recombinant DNA coding for allergen Ole e 9 from olive pollen (Olea europaea) has been cloned and expressed. The above-mentioned allergen has β-1,3-glucanase activity and shows high homology with said proteins. Proteins homologous with said allergen have also been detected in other pollens from other members of the oleacea family (Syringa vulgaris, Ligustrum vulgare and Fraxinus excelsior). The recombinant protein produced in the yeast (Pichia pastoris) is isolated with high yields, it is correctly bonded and shows immunological properties equivalent to those of the natural allergen. Hence, said protein and homologous proteins, the modified forms derived therefrom, the derived fragments containing at least one allergenic epitope can be used in diagnosis and immunotherapy protocols.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4730764-B2
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