| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4dac022280ec96f54c694eb427655932 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 |
| filingDate |
2002-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a40e390b2593e903d5cd7703aa0e6f77 |
| publicationDate |
2002-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-02066628-A2 |
| titleOfInvention |
Supersecretable peptides, processes for their production, and parallel improvement of the secreted form of one or more other polypeptides |
| abstract |
The invention relates to an expression cassette of the form Px-Sx-Bn-(ZR)-transport peptide-(Z1Z2)-protein(Y)-(Z1Z2)-protein (Ym)-T; wherein the expression cassette codes for a transport peptide linked via a sequence Z1Z2 to a second protein which in turn is linked via Z1Z2 to a protein Y1 which either corresponds to Y or can be different from Y and the transport peptide improves the rate of secretion and Y and/or Ym where Px is any promoter DNA sequence selected in such a way that optimal yields of the protein of interest become obtainable; Sx is any DNA which, accordingly, encodes any signal or leader sequence which allows optimal yields; Bn is 1-15 genetically encodable amino acids or a chemical bond; Z is the codon of an amino acid selected from the group comprising Lys and Arg; Z1 is the codon of an amino acid selected from the group comprising Lys and Arg; Z2 is the codon of an amino acid selected from the group comprising Lys and Arg; protein Ym is a DNA sequence encoding any protein which can be produced and secreted by yeast (m=1-5) or is a chemical bon (m=0); R is an argine codon; transport peptide is a DNA sequence encoding a peptide which can be transported efficiently and which can pass membranes; protein Y is a DNA sequence encoding any protein which can be produced and secreted by yeast and whose biological activity, when Ym is not a chemical bond, is not impaired by a basic dipeptide extension or allows degradation of the extension by carboxypeptidases; T is an untranslated DNA sequence advantageous to the expression, and to processes for the production and use thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9950039-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9821032-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9707176-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8410048-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9981013-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8048854-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9987332-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004087766-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9526764-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10434147-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007527206-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10159713-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10117909-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10029011-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10028910-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108866205-A |
| priorityDate |
2001-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |