| abstract |
A compound of formula (I) wherein R?1 and R3¿ are the same or different and represent =O, hydrogen, C¿1-6?alkyl, C1-6dialkyl, =CHC1-C5alkyl, =S, or a 5- or 6-membered anyl; R?4 to R9¿ are the same or different and represent hydrogen, C¿1-6?alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210¿ where R10 is hydrogen or C¿1-6?alkyl, halogen, NO2, OH, CH2OC1-C6alkly, CH2OH, or CF3; Q?1¿ is hydrogen, C¿1-6? alkyl, C1-6dialkyl, C1-6alkoxy, NHAc, NR210¿ where R10 is hydrogen is hydrogen or C¿1-6?alkyl, difluoro, fluoro, =O, or OH; Q?2, Q3, Q4 and Q5¿ are the same or different and represent hydrogen, C¿1-6?alkoxy, OCF3, OCH2CF3, O-cyclopropyl, OCH2-cyclopropyl, C1-C6alkyl, S-alkyl, NR210¿ where R10 is hydrogen or C¿1-6?alkyl, halogen, NO2, OH, CH2OC1-C6alkyl, CH2OH, or a 5-or 6-membered aryl; with the proviso that the compounds [4-(1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]-2-propionic acid, sodium salt and [4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetic acid are excluded; and pharmaceutically acceptable derivatives thereof. |