| abstract |
The invention concerns peptides derived from heliomicine by substitution of one or several amino acids, characterised in that said peptides correspond to formula (I): X1, X2, X3, X4, X5, X6, C7, X8, X9, X10, X11, X12, X13, X14, X15, X16, X17, C18, X19, X20, X21, C22 X23, X24, X25, X26, X27, X28, X29, X30, X31, X32, X33, X34, X35, X36, X37, X38, X39, C40, X41, C42, X43, X44 wherein: X1, X17, X21 X43 are amino acids; X16, X44 are small polar amino acids; X19 is a large polar amino acid; X36 is a small or lightly hydrophobic amino acid; X38 is a lightly hydrophobic or small amino acid; said substitutions being such that: at least one of X1, X17, X21, X43 is a basic or polar, advantageously large polar amino acid, and/or at least one of the amino acids X16, X44 is a basic amino acid or a large polar amino acid, and/or X19 is a basic amino acid, and/or at least one of the amino acids X36, X38 is a strongly hydrophobic amino acid. The invention also concerns antifungal and/or antibacterial compositions comprising at least one of said peptides. |