| abstract |
The present invention provides a new class of antiparatisitcs. The compounds found with the present invention are substituted thiazole- and thiazoline derivatives. The present invention is based on the discovery that such compounds have been found to have antiparasitic activity. The present invention relates to 4-phenyl thiazole derivatives of the following general formula (I): X in formula (I) may be N-R6 or a bond. R1 in formula (I) may be (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl or (3-13C)heteroaryl(1-8C)alkyl. R2 in formula (I) may be SO¿2?NR?7R8, CONR7R8 or NR7R8 R3 and R4¿ in formula (I) may independently be selected from H, halogen, (1-8C)alkyl, hydroxy, (1-8) alkoxy, cyano, nitro, (1-8C) alkoxycarbonyl, (1-8C)(di)alkylamino and (6-14C)(di)arylamino, or R?3 and R4¿ are joined together in a 5-7 membered carbocyclic or heterocyclic ring. R5 in formula (I) may be a halogen atom, (1-8C)alky, hydroxy, (1-8C)alkoxy, cyano, nitro, (1-8C)alkoxycarbonyl, (1-8C)(di)alkylamino or (6-14C)(di)arylamino. 'n' may be 0-3. R6 in formula (I) may be H or (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl or (3-13C)heteroaryl(1-8C)alkyl. R?7 and R8¿ in formula (I) may independently be selected from H, (1-8C)alkyl, (2-8C)alkenyl, (2-8C)alkynyl, (3-8C)cycloalkyl, (2-7C)heterocycloalkyl, (6-14C)aryl, (3-13C)heteroaryl, (6-14C)aryl(1-8C)alkyl and (3-13C)heteroaryl(1-8C)alkyl, or R?7 and R8¿ are joined together in a (2-7C) heterocycloalkyl ring. |